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Article

Distribution of tumor necrosis factor alleles (NcoI RFLP) and their relationship to HLA haplotypes in an Italian population.

Human heredity - 1 Jan 2000

Peruccio D, D'Alfonso S, Borelli I, Amoroso A, Mazzola G, Marsico D, Bersanti M, Richiardi P

Abstract excerpt

The NcoI RFLP of the tumor necrosis factor (TNF) beta gene was analyzed in a panel of 105 unrelated healthy Italian blood donors. The gene frequencies of the 10.5 kb and 5.5 kb allele were 0.73 and 0.27, respectively. The 5.5 kb band was significantly positively associated with HLA-A1, B8, DR17.1...

Topics

Alleles
Blotting, Southern
Deoxyribonucleases, Type II Site-Specific
Gene Frequency
Genetic Linkage
Genotype
HLA Antigens
Haplotypes
Humans
Immunophenotyping
Italy
Lymphotoxin-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 8103036
DOI: 10.1159/000154125

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8103036-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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