Article
No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus.
European journal of immunology - 1 Nov 1993
Pociot F, Wilson A G, Nerup J, Duff G W
Abstract excerpt
Several studies have implicated tumor necrosis factor (TNF)-alpha in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). In the present study we analyzed the first reported TNF-alpha gene polymorphism in relation to IDDM. We have made frequence analysis and tested in vitro lipopolysac...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Haplotypes
- Humans
- In Vitro Techniques
- Infant
- Male
- Monocytes
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Tumor Necrosis Factor-alpha