Article
Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.
The Journal of experimental medicine - 1 Jan 1991
Messer G, Spengler U, Jung M C, Honold G, Blömer K, Pape G R, Riethmüller G, Weiss E H
Abstract excerpt
Since a dysregulated synthesis of tumor necrosis factor alpha (TNF-alpha) may be involved in the pathogenesis of autoimmune diseases, it was of interest to precisely locate the recently reported NcoI restriction fragment length polymorphism (RFLP) of the TNF-alpha region. However, by mapping of 5...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Deoxyribonuclease EcoRI
- Deoxyribonucleases, Type II Site-Specific
- Gene Expression Regulation
- Humans
- Introns
- Lymphocyte Activation
- Lymphocytes
- Lymphotoxin-alpha
- Molecular Sequence Data
- Phytohemagglutinins