Article
Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).
Biochemical and biophysical research communications - 26 Jun 1995
Hamann A, Mantzoros C, Vidal-Puig A, Flier J S
Abstract excerpt
Recent evidence suggests that expression of tumor necrosis factor-alpha (TNF-alpha) by adipocytes is a molecular mediator of insulin resistance in obesity. We have therefore tested the hypothesis that variations within the regulatory region of the TNF-alpha gene, which might cause increased adipo...
Topics
- Adult
- Asian People
- Base Sequence
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Indians, North American
- Middle Aged
- Molecular Sequence Data
- Prevalence
- Promoter Regions, Genetic
- Tumor Necrosis Factor-alpha
- White People