Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).

Biochemical and biophysical research communications - 26 Jun 1995

Hamann A, Mantzoros C, Vidal-Puig A, Flier J S

Abstract excerpt

Recent evidence suggests that expression of tumor necrosis factor-alpha (TNF-alpha) by adipocytes is a molecular mediator of insulin resistance in obesity. We have therefore tested the hypothesis that variations within the regulatory region of the TNF-alpha gene, which might cause increased adipocyte or generalized TNF-alpha synthesis, are associated with NIDDM, a state in which insulin resistance is routinely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Base Sequence
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Prevalence

Share to Promoter Regions, Genetic

Share to White People

Source

Identifiers

PMID: 7598712
DOI: 10.1006/bbrc.1995.1887

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).PMID 7598712Read ↗

The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.Semantic proximity Read ↗

No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.Semantic proximity Read ↗

Tumour necrosis factor-alpha gene promoter polymorphism and decreased insulin resistance.Semantic proximity Read ↗

Association of -308 TNF-alpha promoter polymorphism with type 1 diabetes in North Indians.Semantic proximity Read ↗

Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome.Semantic proximity Read ↗

The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distributionSemantic proximity Read ↗

Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population.Semantic proximity Read ↗

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort.Semantic proximity Read ↗

Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population.Semantic proximity Read ↗

No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin.Semantic proximity Read ↗

Lack of association between the -308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.