Article
Allele-specific quantification of tumor necrosis factor alpha (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals.
Genes and immunity - 1 May 2001
Kaijzel E L, Bayley J P, van Krugten M V, Smith L, van de Linde P, Bakker A M, Breedveld F C, Huizinga T W, Verweij C L
Abstract excerpt
Interindividual variation in the expression of tumor necrosis factor alpha (TNF) suggests the existence of functionally distinct TNF alleles that could play a role in susceptibility to TNF associated diseases such as rheumatoid arthritis (RA). To determine whether differential expression of TNF alleles exists, the relative contribution of TNF alleles in total TNF RNA production in peripheral blood mononuclear...
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