Myasthenia gravis and tumor necrosis factor beta polymorphisms: linkage disequilibrium but no association beyond HLA-B8.

doi:10.1016/s0165-5728(98)00144-1

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Article

Myasthenia gravis and tumor necrosis factor beta polymorphisms: linkage disequilibrium but no association beyond HLA-B8.

Journal of neuroimmunology - 1 Oct 1998

Manz M G, Melms A, Sommer N, Müller C A

Abstract excerpt

Tumor necrosis factor (TNF) may contribute to the susceptibility for autoimmune diseases. We examined TNFbeta gene polymorphisms detected by AspHI and NcoI digestion of genomic DNA in patients with myasthenia gravis (n=105) and healthy controls (n=114). In both groups, the frequencies of TNFbeta...

Topics

Adult
Aged
Alleles
Female
HLA-B8 Antigen
HLA-DR Antigens
Humans
Linkage Disequilibrium
Lymphotoxin-alpha
Male
Middle Aged
Myasthenia Gravis

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