Article
Restriction fragment length polymorphism (RFLP) analysis in the TNF genes of patients with systemic lupus erythematosus (SLE).
Clinical and experimental rheumatology - 1 Jan 2000
Tomita Y, Hashimoto S, Yamagami K, Sawada S, Horie T
Abstract excerpt
Although systemic lupus erythematosus (SLE) is known to be positively associated with certain major histocompatibility complex (MHC) class I and/or class II antigens, it is not clear whether the MHC genes are the predisposing genes of the disease rather than markers for other closely linked gene(s). Because of the involvement of tumor necrosis factor (TNF) in the inflammation process and localization of the TNF...
Topics
- Alleles
- DNA Probes
- Deoxyribonucleases, Type II Site-Specific
- Gene Frequency
- Genetic Markers
- HLA Antigens
- Humans
- Lupus Erythematosus, Systemic
- Lymphotoxin-alpha
- Polymorphism, Restriction Fragment Length