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Article

A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Jul 1995

Wilson A G, de Vries N, van de Putte L B, Duff G W

Abstract excerpt

OBJECTIVE: To determine whether a polymorphism within the tumour necrosis factor alpha (TNF alpha) gene is associated with susceptibility to, or severity of, rheumatoid arthritis (RA). METHODS: Consecutive patients with recent onset RA were enrolled in a prospective trial. DNA was collected, disease activity was measured at presentation, and radiographic progression at three years was assessed. Typing of TNF...

Topics

Arthritis, Rheumatoid
Base Sequence
Disease Progression
Female
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Prospective Studies

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 7668906
DOI: 10.1136/ard.54.7.601
PMCID: PMC1009943

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7668906-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.PMID 7668906Read ↗

TNF-alpha -308 promoter polymorphism in patients with rheumatoid arthritis.Semantic proximity Read ↗

TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis.Semantic proximity Read ↗

Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis.Semantic proximity Read ↗

No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis.Semantic proximity Read ↗

Lack of tumor necrosis factor alpha gene polymorphism -857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients.Semantic proximity Read ↗

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.Semantic proximity Read ↗

Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis.Semantic proximity Read ↗

TNF Nco-I RFLP is not an independent risk factor in rheumatoid arthritis.Semantic proximity Read ↗

Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease?Semantic proximity Read ↗

Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population.Semantic proximity Read ↗

Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in CaucasiansSemantic proximity Read ↗

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