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Article

Tumor necrosis factor polymorphism in multiple sclerosis: no additional association independent of HLA.

Journal of neuroimmunology - 1 Apr 1994

Roth M P, Nogueira L, Coppin H, Clanet M, Clayton J, Cambon-Thomsen A

Abstract excerpt

In order to investigate whether genes coding for tumor necrosis factors (TNF) contribute to the pathogenesis of multiple sclerosis (MS) and also whether they have a non-random association with the MS associated HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype, 40 MS patients and their parents were characterized at four polymorphic loci in the region of the TNF genes: a NcoI RFLP and three microsatellites. We were able...

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Source

Identifiers

PMID: 8157738
DOI: 10.1016/0165-5728(94)90133-3

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tumor necrosis factor polymorphism in multiple sclerosis: no additional association independent of HLA.PMID 8157738Read ↗

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Interaction of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis.Semantic proximity Read ↗

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Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis.Semantic proximity Read ↗

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TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.Semantic proximity Read ↗

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