Article
Polymorphism of the 5' flanking region of the HLA-DQA1 gene in coeliac disease.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 1993
de la Paz Bettinotti M, Kolek A, Brünnler G, Haas P, Paul C, Hochberger M, Bartova A, Kimura A, Sasazuki T, Albert E D
Abstract excerpt
Coeliac disease (CD) is associated with particular HLA genotypes. The susceptibility gene (or genes) has been mapped to the class II region, most probably to the DQ loci. Polymorphism of the upstream promoter region of the DQA1 gene (QAP) has been recently reported. At least ten variants or QAP alleles have been found, some of which are present in the cis-acting regulatory sequences. Allelic differences in DQ...
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