Article
Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease.
Annals of human genetics - 1 May 1999
Brett P M, Yiannakou J Y, Morris M A, Vaughan R, Curtis D, Ciclitira P J
Abstract excerpt
Coeliac Disease (CD) is a gluten sensitive enteropathy characterised by villous atrophy and crypt cell hyperplasia. It has a very strong HLA class II association to the DQ locus. The nature of the involvement of the DQ locus in the susceptibility to CD has been examined by tissue culture experiments, association and peptide binding studies. We examined the role of the DQ molecules in the pathogenesis from the...
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