Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.

Scandinavian journal of gastroenterology - 1 Feb 2006

Karinen Hannele, Kärkkäinen Päivi, Pihlajamäki Jussi, Janatuinen Esko, Heikkinen Markku, Julkunen Risto, Kosma Veli-Matti, Naukkarinen Anita, Laakso Markku

Abstract excerpt

OBJECTIVE: Coeliac disease (CD) susceptibility has been shown to be associated with the HLA alleles DQA1*0501 and DQB1*0201. This HLA-associated risk has been estimated to account for 29-40% of the genetic component of CD. Conflicting data have been published on the gene dose effect of these HLA alleles on the risk and severity of CD. In this study the aim was to investigate the association between the number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Celiac Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Frequency

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to Severity of Illness Index

Source

Identifiers

PMID: 16484124
DOI: 10.1080/00365520500206277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.PMID 16484124Read ↗

Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.Semantic proximity Read ↗

HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease.Semantic proximity Read ↗

Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.Semantic proximity Read ↗

HLA DQ gene dosage and risk and severity of celiac disease.Semantic proximity Read ↗

The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients.Semantic proximity Read ↗

Association between genotypes and phenotypes in coeliac disease.Semantic proximity Read ↗

Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins.Semantic proximity Read ↗

A gene dosage effect of the DQA1∗0501/DQB1∗0201 allelic combination influences the clinical heterogeneity of celiac diseaseSemantic proximity Read ↗

MHC class I chain related gene A (MICA) modulates the development of coeliac disease in patients with the high risk heterodimer DQA1*0501/DQB1*0201.Semantic proximity Read ↗

Contribution of histological, serological, and genetic factors to the clinical heterogeneity of adult-onset coeliac disease.Semantic proximity Read ↗

Genetics of coeliac diseaseSemantic proximity Read ↗

HLA related genetic risk for coeliac disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.