Article
Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients.
Genes and immunity - 1 May 2004
van Belzen M J, Koeleman B P C, Crusius J B A, Meijer J W R, Bardoel A F J, Pearson P L, Sandkuijl L A, Houwen R H J, Wijmenga C
Abstract excerpt
The major genetic susceptibility to coeliac disease is contributed by the human leukocyte antigen (HLA) region. The primary association is with the HLA-DQ2 molecule, encoded by the DQA1*05 and DQB1*02 alleles, which is expressed by over 90% of patients. The aim of our study was to perform an extensive scan of the entire HLA region to determine whether there is evidence for the presence of additional HLA...
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