HLA-DQA1*0501 and DQB1*02 homozygosity and disease susceptibility in Spanish coeliac patients.

Article

HLA-DQA10501 and DQB102 homozygosity and disease susceptibility in Spanish coeliac patients.

Experimental and clinical immunogenetics - 1 Jan 1997

Arranz E, Telleria J J, Sanz A, Martin J F, Alonso M, Calvo C, Blanco-Quirós A

Abstract excerpt

Coeliac disease (CD) susceptibility is strongly associated with HLA-DQA1*0501 and DQB1*02 alleles. There are discordant reports on whether homozygosity increases the risk. We genotyped HLA-DQA1*0501 and DQB1*02 in 50 CD patients, 100 parents, and 50 controls. Most patients (96%) were positive for...

Topics

Alleles
Celiac Disease
Child, Preschool
Female
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Homozygote
Humans
Male

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