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Article

ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.

Neurology - 1 Jan 1997

Blacker D, Haines J L, Rodes L, Terwedow H, Go R C, Harrell L E, Perry R T, Bassett S S, Chase G, Meyers D, Albert M S, Tanzi R

Abstract excerpt

OBJECTIVE: To explore the impact of apoE-4 on Alzheimer's disease (AD) and its age at onset. DESIGN: A genetic linkage study using affected relative pairs, predominantly siblings. SETTING: Three academic medical centers ascertained subjects from memory disorder clinics, nursing homes, and the local community. SUBJECTS: 310 families including 679 subjects with AD by NINCDS/ADRDA and/or Khachaturian criteria and...

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Identifiers

PMID: 9008509
DOI: 10.1212/wnl.48.1.139

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