Article
APOE genotype effects on Alzheimer's disease onset and epidemiology.
Journal of molecular neuroscience : MN - 1 Jan 2004
Ashford J Wesson
Abstract excerpt
The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE...
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