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Article

The interplay of APOE genotype, plasma levels, and cognitive functions in middle-aged adults with a parental history of Alzheimer's disease.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jul 2026

Mattar Yomna Amr, Refaat Osama, El-Makawi Shirin, Medhat Engy, Khalifa Dalia

Abstract excerpt

BACKGROUND: Family history and APOE ε4 carriage represent the strongest non-modifiable Alzheimer's disease (AD) risk factors after advancing age. Early identification of cognitive markers in individuals at risk is essential for effective intervention strategies. OBJECTIVES: To assess global cognition and its executive function subset in middle-aged offspring of AD patients versus controls, and to examine the...

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Source

Identifiers

PMID: 42109080
DOI: 10.1080/15622975.2026.2666647

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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