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Article

Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jul 2012

Donix Markus, Ercoli Linda M, Siddarth Prabha, Brown Jesse A, Martin-Harris Laurel, Burggren Alison C, Miller Karen J, Small Gary W, Bookheimer Susan Y

Abstract excerpt

OBJECTIVES: Identification of risk factors for Alzheimer disease (AD) is critical for establishing effective diagnostic and therapeutic strategies. Carrying the ε4 allele of the apolipoprotein E gene (APOE4) and having a family history of the disease are two such factors, with family history risk reflecting additional yet unknown or rarely studied genetic and perhaps nongenetic risks. Our aim was to determine the...

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Identifiers

PMID: 21849821
DOI: 10.1097/JGP.0b013e3182107e6a
PMCID: PMC3816758

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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