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Article

Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway.

Nature neuroscience - 1 Jul 2024

Narasimhan Sneha, Holtzman David M, Apostolova Liana G, Cruchaga Carlos, Masters Colin L, Hardy John, Villemagne Victor L, Bell Joanne, Cho Min, Hampel Harald

Abstract excerpt

Alzheimer's disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) has remained the strongest single genome-wide associated risk variant in AD. Scientific advances in APOE biology, AD pathophysiology and ApoE-targeted therapies have brought APOE to the forefront of research, with potential translation...

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Identifiers

PMID: 38898183
DOI: 10.1038/s41593-024-01669-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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