Article
Age at onset in two common neurodegenerative diseases is genetically controlled.
American journal of human genetics - 1 Apr 2002
Li Yi-Ju, Scott William K, Hedges Dale J, Zhang Fengyu, Gaskell P Craig, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Pahwa Rajesh, Stern Matthew B, Hiner Bradley C, Jankovic Joseph, Allen Fred A, Goetz Christopher G, Mastaglia Frank, Stajich Jeffrey M, Gibson Rachel A, Middleton Lefkos T, Saunders Ann M, Scott Burton L, Small Gary W, Nicodemus Kristin K, Reed Allison D, Schmechel Donald E, Welsh-Bohmer Kathleen A, Conneally P Michael, Roses Allen D, Gilbert John R, Vance Jeffery M, Haines Jonathan L, Pericak-Vance Margaret A
Abstract excerpt
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD =...
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