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Behavioural effects of the ACE insertion/deletion polymorphism in Alzheimer's disease depend upon stratification according to APOE-ϵ4 carrier status.

Cognitive neuropsychiatry - 1 Jul 2021

Oliveira Fabricio Ferreira de, de Almeida Sandro Soares, Smith Marilia Cardoso, Bertolucci Paulo Henrique Ferreira

Abstract excerpt

Introduction: The inherited risk of late-onset Alzheimer's disease (AD) is genetically determined. We aimed to examine associations of genetic variants of APOE and ACE with age at AD onset and with neuropsychiatric symptoms according to each dementia stage.Methods: Consecutive outpatients with AD were assessed for demographic features, Clinical Dementia Rating scores, and the 10-item Neuropsychiatric Inventory,...

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PMID: 34034613
DOI: 10.1080/13546805.2021.1931085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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