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Article

Specificities of human TAP alleles for HLA-B27 binding peptides.

Arthritis and rheumatism - 1 Nov 1996

Kuipers J G, Raybourne R B, Williams K M, Zeidler H, Yu D T

Abstract excerpt

OBJECTIVE: Allelic TAP polymorphism has been linked to susceptibility to Reiter's syndrome and was suggested to influence disease phenotype in HLA-B27 positive patients with ankylosing spondylitis. In the present study, we examined whether the human TAP alleles functionally differ in their transl...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Alleles
Cell Line
Epitopes
HLA-B27 Antigen
Humans
Major Histocompatibility Complex
Protein Biosynthesis
Spondylitis, Ankylosing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8912512
DOI: 10.1002/art.1780391116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8912512-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Specificities of human TAP alleles for HLA-B27 binding peptides.PMID 8912512Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis.Semantic proximity Read ↗

TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis.Semantic proximity Read ↗

Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection.Semantic proximity Read ↗

Susceptibility to Reiter's syndrome is associated with alleles of TAP genes.Semantic proximity Read ↗

Homozygous human TAP peptide transporter mutation in HLA class I deficiency.Semantic proximity Read ↗

The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP associationSemantic proximity Read ↗

Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP).Semantic proximity Read ↗

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.Semantic proximity Read ↗

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.Semantic proximity Read ↗

Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules.Semantic proximity Read ↗

Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis.Semantic proximity Read ↗

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