Article
Homozygous human TAP peptide transporter mutation in HLA class I deficiency.
Science (New York, N.Y.) - 8 Jul 1994
de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis S H, Donato L, Bausinger H, Laforet M
Abstract excerpt
Human lymphocyte antigen (HLA) class I proteins of the major histocompatibility complex are largely dependent for expression on small peptides supplied to them by transporter associated with antigen processing (TAP) protein. An inherited human deficiency in the TAP transporter was identified in t...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Adolescent
- Amino Acid Sequence
- Antigens, CD
- Antigens, CD1
- Base Sequence
- Carrier Proteins
- Child
- Female
- Histocompatibility Antigens Class I
- Homozygote
- Humans