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Article

Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules.

International immunology - 1 Nov 1998

Gatfield J, Lammert E, Nickolaus P, Münz C, Rothenfusser S, Fisch P, Stevanović S, Schild H, Rammensee H G, Arnold D

Abstract excerpt

The immediate early protein ICP47 of the Herpes simplex virus is known to block the human transporter associated with antigen processing (TAP), thereby creating a TAP-deficient phenotype in any human cell transfected with the corresponding cDNA. Exploiting this inhibitory activity, we constructed a selection of human cell lines each co-expressing one of the cDNAs of human leukocyte antigen (HLA) class I alleles...

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Identifiers

PMID: 9846695
DOI: 10.1093/intimm/10.11.1665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cell lines transfected with the TAP inhibitor ICP47 allow testing peptide binding to a variety of HLA class I molecules.PMID 9846695Read ↗

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