Article
HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.
Immunity - 1 May 1998
Peh C A, Burrows S R, Barnden M, Khanna R, Cresswell P, Moss D J, McCluskey J
Abstract excerpt
Tapasin is a resident ER protein believed to be critical for antigen presentation by HLA class I molecules. We demonstrate that allelic variation in MHC class I molecules influences their dependence on tapasin for peptide loading and antigen presentation. HLA-B*2705 molecules achieve high levels...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Antigen Presentation
- Antiporters
- Cells, Cultured
- Disease Susceptibility
- HLA-B Antigens
- HLA-B27 Antigen
- HLA-B44 Antigen
- Humans
- Immunoglobulins