Article
Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1997
Daniel S, Caillat-Zucman S, Hammer J, Bach J F, van Endert P M
Abstract excerpt
The polymorphic TAP (TAP1 and TAP2) genes code for a heteromeric complex that translocates cytosolic peptides across the membrane of the endoplasmic reticulum where they associate with MHC class I molecules. In the rat, extensive TAP2 polymorphism modifies the spectrum of peptides presented by MHC class I molecules on the cell surface. Although polymorphism of human TAP proteins is more limited, it has been...
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