Article
A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.
European journal of immunology - 1 Aug 1996
Armandola E A, Momburg F, Nijenhuis M, Bulbuc N, Früh K, Hämmerling G J
Abstract excerpt
The heterodimeric transporter associated with antigen processing (TAP1/TAP2) translocates peptides from the cytosol into the endoplasmic reticulum where loading of major histocompatibility complex class I molecules takes place. TAP transporters from different species are known to exhibit distinct...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Base Sequence
- Biological Transport
- Epitopes
- Humans
- Mice
- Molecular Sequence Data
- Peptides
- Phenotype
- Point Mutation
- Rats
- Rats, Inbred Lew
- Species Specificity