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Article

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.

European journal of immunology - 1 Aug 1996

Armandola E A, Momburg F, Nijenhuis M, Bulbuc N, Früh K, Hämmerling G J

Abstract excerpt

The heterodimeric transporter associated with antigen processing (TAP1/TAP2) translocates peptides from the cytosol into the endoplasmic reticulum where loading of major histocompatibility complex class I molecules takes place. TAP transporters from different species are known to exhibit distinct transport specificities with regard to the C-terminal amino acid (aa) of peptides. Thus, human TAP (hTAP), and rat TAP...

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Source

Identifiers

PMID: 8765016
DOI: 10.1002/eji.1830260813

Genes

TAP2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.PMID 8765016Read ↗

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A Detailed Analysis of the Murine TAP Transporter Substrate SpecificitySemantic proximity Read ↗

Effect of mutated transporters associated with antigen-processing 2 on characteristic major histocompatibility complex binding peptides: analysis using electrospray ionization tandem mass spectrometry.Semantic proximity Read ↗

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Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism.Semantic proximity Read ↗

Exploring the minimal functional unit of the transporter associated with antigen processing.Semantic proximity Read ↗

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Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

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