Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Annals of the rheumatic diseases - 1 Mar 2017

Chen Liye, Shi Hui, Yuan Jack, Bowness Paul

Abstract excerpt

OBJECTIVE: Association of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has recently been reported. We studied the effect of P97 variations on cell surface expression of the AS-associated HLA-B*27 and HLA-B*51, and the AS-protective HLA-B*7. METHODS: Flow cytometry was used to measure surface expression of HLA-B*27 in C1R/HeLa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Asparagine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to beta 2-Microglobulin

Share to HLA-B27 Antigen

Share to HLA-B51 Antigen

Share to HLA-B7 Antigen

Share to Minor Histocompatibility Antigens

Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 27515058
DOI: 10.1136/annrheumdis-2016-209512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.PMID 27515058Read ↗

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.Semantic proximity Read ↗

Polymorphism of HLA-B27: 105 subtypes currently known.Semantic proximity Read ↗

HLA-B27Semantic proximity Read ↗

MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions.Semantic proximity Read ↗

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.Semantic proximity Read ↗

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.Semantic proximity Read ↗

HLA-B27 Subtypes Predisposing to Ankylosing Spondylitis Accumulate in an Endoplasmic Reticulum-Derived Compartment Apart From the Peptide-Loading Complex.Semantic proximity Read ↗

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.Semantic proximity Read ↗

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis.Semantic proximity Read ↗

HLA-B*2704, an allotype associated with ankylosing spondylitis, is critically dependent on transporter associated with antigen processing and relatively independent of tapasin and immunoproteasome for maturation, surface expression, and T cell recognition: relationship to B*2705 and B*2706.Semantic proximity Read ↗

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface.Semantic proximity Read ↗

Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.