Article
TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis.
Human immunology - 1 Dec 1995
Westman P, Partanen J, Leirisalo-Repo M, Koskimies S
Abstract excerpt
The polymorphic TAP1 and TAP2 genes encode subunits of the transporter that delivers peptides to the HLA class I molecules. Because the polymorphism of the TAP genes has been shown to affect peptide transport, it has been suggested that TAP genes are potential regulators of the immune response. W...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Arthritis, Reactive
- Case-Control Studies
- Finland
- HLA-B27 Antigen
- HLA-DQ Antigens
- HLA-DQ alpha-Chains