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Article

Identification of a missense mutation and several polymorphisms in the proenkephalin A gene of schizophrenic patients.

American journal of medical genetics - 20 Sept 1996

Mikesell M J, Sobell J L, Sommer S S, McMurray C T

Abstract excerpt

Schizophrenia is a complex and severe disorder of unknown cause and pathophysiology. In this study, we examined the opioid hypothesis for schizophrenia at the molecular level, focusing on the dopamine-regulated proenkephalin A gene (chromosome 8q11.23-q12). We have screened 150 schizophrenic patients for sequence variations within the promoter region, entire coding sequence, and 3'-untranslated region. We find...

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Source

Identifiers

PMID: 8886162
DOI: 10.1002/(SICI)1096-8628(19960920)67:5<459::AID-AJMG4>3.0.CO;2-F

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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