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Article

Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia.

American journal of medical genetics - 7 Sept 1998

Kawanishi Y, Harada S, Tachikawa H, Okubo T, Shiraishi H

Abstract excerpt

Dysfunction of serotonin systems has been implicated in schizophrenia. In the present study, the human 5-HT1A receptor gene containing the 5' untranslated region was screened in order to detect genetic variations, through which alteration of protein function or level of expression might contribute to schizophrenia. Genomic DNAs were isolated from whole-blood samples of 61 unrelated schizophrenic patients and 100...

Topics

Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Humans
Mutation
Promoter Regions, Genetic
Receptors, Serotonin
Schizophrenia

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9754630
DOI: 10.1002/(sici)1096-8628(19980907)81:5<434::aid-ajmg13>3.0.co;2-d

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