Article
A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.
Human molecular genetics - 15 Jun 2008
Edenberg Howard J, Wang Jun, Tian Huijun, Pochareddy Sirisha, Xuei Xiaoling, Wetherill Leah, Goate Alison, Hinrichs Tony, Kuperman Samuel, Nurnberger John I, Schuckit Marc, Tischfield Jay A, Foroud Tatiana
Abstract excerpt
Variations in OPRK1, which encodes the kappa-opioid receptor, are associated with the risk for alcohol dependence. Sequencing DNAs with higher and lower risk haplotypes revealed an insertion/deletion (indel) with a net addition of 830 bp located 1986 bp upstream of the translation start site (1389 bp upstream of the transcription start site). We demonstrated that the upstream region extending from -1647 to -10 bp...
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