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Article

Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction.

Pharmacogenetics - 1 Dec 2004

Yuferov Vadim, Fussell David, LaForge K Steven, Nielsen David A, Gordon Derek, Ho Ann, Leal Suzanne M, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

The kappa opioid receptor (KOR) plays a role in stress responsivity, opiate withdrawal and responses to cocaine. KOR activation by its endogenous ligand dynorphin A(1-17) decreases basal and drug-induced striatal levels of dopamine. The complete structure of the human KOR gene (hOPRK1) has not been previously determined. This study: (i) characterized the genomic structure of the hOPRK1 gene; (ii) identified...

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Identifiers

PMID: 15608558
DOI: 10.1097/00008571-200412000-00002
PMCID: PMC6141019

Genes

OPRK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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