Gly(247)-->Asp proenkephalin A mutation is rare in schizophrenia populations.

doi:10.1002/(sici)1096-8628(19970418)74:2<213::aid-ajmg21>3.0.co;2-k

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Article

Gly(247)-->Asp proenkephalin A mutation is rare in schizophrenia populations.

American journal of medical genetics - 18 Apr 1997

Mikesell M J, Barron Y D, Nimgaonkar V L, Sobell J L, Sommer S S, McMurray C T

Abstract excerpt

Schizophrenia is a complex and severe disorder of unknown cause and pathophysiology. In previous work examining an opioid hypothesis for schizophrenia, we identified a missense mutation (Gly(247)-->Asp) in the proenkephalin A gene of one African-American patient. In the current study involving an...

Topics

Aspartic Acid
Enkephalins
Female
Glycine
Humans
Male
Mutation
Protein Precursors
Schizophrenia

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