Article
Gly(247)-->Asp proenkephalin A mutation is rare in schizophrenia populations.
American journal of medical genetics - 18 Apr 1997
Mikesell M J, Barron Y D, Nimgaonkar V L, Sobell J L, Sommer S S, McMurray C T
Abstract excerpt
Schizophrenia is a complex and severe disorder of unknown cause and pathophysiology. In previous work examining an opioid hypothesis for schizophrenia, we identified a missense mutation (Gly(247)-->Asp) in the proenkephalin A gene of one African-American patient. In the current study involving an extended set of African-American and other patients, we sought to identify additional mutant alleles and to determine...
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