Article
An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males.
Acta psychiatrica Scandinavica - 1 Oct 2009
Koefoed P, Hansen T V O, Woldbye D P D, Werge T, Mors O, Hansen T, Jakobsen K D, Nordentoft M, Wang A, Bolwig T G, Rehfeld J F
Abstract excerpt
OBJECTIVE: To identify whether a genetic variation (rs1800857; IVS1-5T>C) in the neuropeptide cholecystokinin-A receptor (CCKAR) gene is a risk factor in the pathogenesis of schizophrenia. METHOD: The variation was analysed in a case-control design comprising 508 patients with schizophrenia and 1619 control subjects. A possible functional impact of this variant on CCKAR protein synthesis through alterations in...
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