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Article

Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder.

Molecular psychiatry - 1 Jan 1998

Bowen T, Norton N, Jacobsen N J, Guy C, Daniels J K, Sanders R D, Cardno A G, Jones L A, Murphy K C, McGuffin P, Craddock N, O'Donovan M C, Owen M J

Abstract excerpt

The evidence for a significant genetic contribution to the functional psychoses (schizophrenia and bipolar disorder) is now well established. However, in both cases, the non-mendelian mode of inheritance has made the identification of susceptibility loci particularly challenging. The neuropeptide cholecystokinin (CCK) is present both in the gut and the CNS. Studies of CCK-like immunoreactivity and CCK mRNA levels...

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Identifiers

PMID: 9491815
DOI: 10.1038/sj.mp.4000293

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder.PMID 9491815Read ↗

Novel polymorphism in the promoter and coding regions of the human cholecystokinin B receptor gene: an association analysis with schizophrenia.Semantic proximity Read ↗

Novel polymorphisms of the human cholecystokinin A receptor gene: an association analysis with schizophrenia.Semantic proximity Read ↗

An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males.Semantic proximity Read ↗

Possible association of a cholecystokinin promoter variant to schizophrenia.Semantic proximity Read ↗

Investigation of allelic heterogeneity of the CCK-A receptor gene in paranoid schizophrenia.Semantic proximity Read ↗

[Deep sequencing for cholecystokinin a receptor gene to get loci associated with schizophrenia].Semantic proximity Read ↗

Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.Semantic proximity Read ↗

Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia.Semantic proximity Read ↗

No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence.Semantic proximity Read ↗

Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects.Semantic proximity Read ↗

Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study.Semantic proximity Read ↗

[Relationship between cholecystokinin gene -45C/T polymorphism and schizophrenia and its application in forensic medicine].Semantic proximity Read ↗

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