Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas.

doi:10.1002/(SICI)1098-2264(199606)16:2<138::AID-GCC8>3.0.CO;2-0

Back to search

Article

Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas.

Genes, chromosomes & cancer - 1 Jun 1996

Raskind W H, Conrad E U, Matsushita M

Abstract excerpt

Many tumors exhibit loss of heterozygosity (LOH) for polymorphic markers in regions of the genome that contain genes whose normal function can suppress tumor growth. Mapping of regions of LOH can help identify putative tumor suppressor loci that play a role in the pathogenesis of a disease. We ev...

Topics

Bone Neoplasms
Chondrosarcoma
Chromosome Mapping
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Gene Deletion
Genetic Markers
Genotype
Heterozygote
Humans
Polymorphism, Restriction Fragment Length

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.