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Article

Losses of heterozygosity in oral and oropharyngeal epithelial carcinomas.

Cancer genetics and cytogenetics - 1 Apr 2000

Grati F R, Sirchia S M, Garagiola I, Sironi E, Galioto S, Rossella F, Serafini P, Dulcetti F, Bozzetti A, Brusati R, Simoni G

Abstract excerpt

We analyzed 25 oral and oropharyngeal epithelial carcinomas for loss of heterozygosity (LOH) and microsatellite instability by using 55 oligonucleotide repeat markers located in 45 chromosomal regions. The aim was to identify which chromosomal regions and tumor-suppressor genes (TSGs) are preferentially lost in these tumors and to relate LOH at specific loci to clinicopathologic data. The analysis was performed...

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PMID: 10731592
DOI: 10.1016/s0165-4608(99)00199-5

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