Article
Loss of heterozygosity for 10q loci in human gliomas.
Genes, chromosomes & cancer - 1 Jul 1992
Rasheed B K, Fuller G N, Friedman A H, Bigner D D, Bigner S H
Abstract excerpt
Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to det...
Topics
- Alleles
- Brain Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- DNA Probes
- Female
- Genetic Markers
- Glioblastoma
- Glioma
- Humans
- Male
- Polymorphism, Restriction Fragment Length