Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas.

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Article

Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas.

Anticancer research - 1 Jan 2000

Yamaguchi T, Toguchida J, Wadayama B, Kanoe H, Nakayama T, Ishizaki K, Ikenaga M, Kotoura Y, Sasaki M S

Abstract excerpt

Loss of heterozygosity (LOH) of chromosomes 13q and 17p and mutations of the retinoblastoma (Rb) and p53 gene were studied in 28 tumors from 22 patients with chondrosarcomas. Allele loss at polymorphic loci on 13q was found in 36% of tumors and the frequency was much higher in grade II (56%) or h...

Topics

Adolescent
Adult
Aged
Alleles
Amino Acid Sequence
Base Sequence
Bone Neoplasms
Chondrosarcoma
Chromosome Mapping
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Female
Gene Deletion
Genes, Retinoblastoma
Genes, p53
Humans
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 8712735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8712735-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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