Article
Regulation of SOS mutagenesis by proteolysis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Frank E G, Ennis D G, Gonzalez M, Levine A S, Woodgate R
Abstract excerpt
DNA damage-inducible mutagenesis in Escherichia coli is largely dependent upon the activity of the UmuD (UmuD') and UmuC proteins. The intracellular level of these proteins is tightly regulated at both the transcriptional and the posttranslational levels. Such regulation presumably allows cells to deal with DNA damage via error-free repair pathways before being committed to error-prone pathways. We have recently...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.