Article
Regulation of SOS mutagenesis by proteolysis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Frank E G, Ennis D G, Gonzalez M, Levine A S, Woodgate R
Abstract excerpt
DNA damage-inducible mutagenesis in Escherichia coli is largely dependent upon the activity of the UmuD (UmuD') and UmuC proteins. The intracellular level of these proteins is tightly regulated at both the transcriptional and the posttranslational levels. Such regulation presumably allows cells t...
Topics
- ATPases Associated with Diverse Cellular Activities
- Adenosine Triphosphatases
- Bacterial Proteins
- DNA Damage
- DNA-Directed DNA Polymerase
- Endopeptidase Clp
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genotype
- Molecular Chaperones
- Mutagenesis
- Protein Processing, Post-Translational
- Restriction Mapping
- SOS Response, Genetics
- Transcription, Genetic
- Ultraviolet Rays