Article
The UmuD' protein filament and its potential role in damage induced mutagenesis.
Structure (London, England : 1993) - 15 Dec 1996
Peat T S, Frank E G, McDonald J P, Levine A S, Woodgate R, Hendrickson W A
Abstract excerpt
BACKGROUND: Damage induced 'SOS mutagenesis' may occur transiently as part of the global SOS response to DNA damage in bacteria. A key participant in this process is the UmuD protein, which is produced in an inactive from but converted to the active form, UmuD', by a RecA-mediated self-cleavage r...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Cross-Linking Reagents
- Crystallography, X-Ray
- DNA
- DNA Damage
- DNA-Directed DNA Polymerase
- Dimerization
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Escherichia coli Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Protein Structure, Secondary
- Rec A Recombinases
- Recombinant Proteins