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Article

Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage.

Journal of bacteriology - 1 Jan 2001

Sutton M D, Kim M, Walker G C

Abstract excerpt

Most translesion DNA synthesis (TLS) in Escherichia coli is dependent upon the products of the umuDC genes, which encode a DNA polymerase, DNA polymerase V, with the unique ability to replicate over a variety of DNA lesions, including cyclobutane dimers and abasic sites. The UmuD protein is activated for its role in TLS by a RecA-single-stranded DNA (ssDNA)-facilitated self-cleavage event that serves to remove...

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Source

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Identifiers

PMID: 11114935
DOI: 10.1128/JB.183.1.347-357.2001
PMCID: PMC94884

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Source receipt: pubmed, retrieved 7 Sept 2026.

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