Article
Insights into the complex levels of regulation imposed on Escherichia coli DNA polymerase V.
DNA repair - 1 Aug 2016
Goodman Myron F, McDonald John P, Jaszczur Malgorzata M, Woodgate Roger
Abstract excerpt
It is now close to 40 years since the isolation of non-mutable umu/uvm strains of Escherichia coli and the realization that damage induced mutagenesis in E.coli is not a passive process. Early models of mutagenesis envisioned the Umu proteins as accessory factors to the cell's replicase that not only reduced its normally high fidelity, but also allowed the enzyme to traverse otherwise replication-blocking lesions...
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