Article
Deciphering proteolysis pathways for the error-prone DNA polymerase in cyanobacteria.
Environmental microbiology - 1 Feb 2021
Jin Haojie, Kim Rick, Bhaya Devaki
Abstract excerpt
Protein quality control pathways require AAA+ proteases, such as Clp and Lon. Lon protease maintains UmuD, an important component of the error-prone DNA repair polymerase (Pol V), at very low levels in E. coli. Most members of the phylum Cyanobacteria lack Lon (including the model cyanobacterium, Synechocystis sp. PCC6803), so maintenance of UmuD at low levels must employ different proteases. We demonstrate that...
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