Article
Novel Escherichia coli umuD' mutants: structure-function insights into SOS mutagenesis.
Journal of bacteriology - 1 Sept 1998
McLenigan M, Peat T S, Frank E G, McDonald J P, Gonzalez M, Levine A S, Hendrickson W A, Woodgate R
Abstract excerpt
Although it has been 10 years since the discovery that the Escherichia coli UmuD protein undergoes a RecA-mediated cleavage reaction to generate mutagenically active UmuD', the function of UmuD' has yet to be determined. In an attempt to elucidate the role of UmuD' in SOS mutagenesis, we have uti...
Topics
- Bacterial Proteins
- Cloning, Molecular
- DNA-Directed DNA Polymerase
- Dimerization
- Escherichia coli
- Escherichia coli Proteins
- Genes, Dominant
- Genes, Recessive
- Mutagenesis
- Phenotype
- Plasmids
- SOS Response, Genetics
- Structure-Activity Relationship