Article
Gene family use and somatic mutation in primary and secondary fluorescein-specific IgM antibody responses.
Immunology and cell biology - 1 Jun 1996
Van der Keyl H, Hsu C, Tolat A, Kansil S, Dalesandro M R, Dorer D R, Caton A, Owen J A
Abstract excerpt
A comparative analysis of the DNA sequences of primary and secondary IgM, fluorescein-specific antibodies was performed. These antibodies were secreted by hybridomas generated following fusion of immunized BALB/c mouse lymphocytes and SP2/0 myeloma cells. Our results show that primary and secondary fluorescein-specific IgM antibodies use a variety of segments from the variable region of the immunoglobulin heavy...
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