Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.

doi:10.1046/j.1440-1711.2000.00903.x

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Article

Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.

Immunology and cell biology - 1 Jun 2000

van der Keyl H, Gellad Z F, Owen J A

Abstract excerpt

The present paper describes a comparative analysis of light chains associated with primary and secondary IgM, as well as with secondary IgG antibodies to fluorescein, undertaken in order to explore the relationship between light chain somatic hypermutation and the isotype switch. The data reveal a disparity in the frequency of somatic hypermutation of secondary IgM heavy versus light chains. Among 20 secondary...

Topics

Animals
Base Sequence
Female
Immunoglobulin Class Switching
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Immunoglobulin M
Immunoglobulin Variable Region
Kinetics
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 10849110
DOI: 10.1046/j.1440-1711.2000.00903.x

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