Article
The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1990
Clarke S, Rickert R, Wloch M K, Staudt L, Gerhard W, Weigert M
Abstract excerpt
We have determined the nucleotide sequences of the expressed VH and Vk genes from 13 secondary (2 degrees) hemagglutinin (HA) (Sb) specific hybridomas derived from a single mouse. These antibodies share an Id, H37-68 (68Id) that dominates the 2 degrees HA(Sb) response in this mouse, but is rare o...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Viral
- Antibody Diversity
- Base Sequence
- Blotting, Southern
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Hemagglutinins, Viral
- Immunoglobulin Idiotypes
- Immunologic Memory
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data