Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response.

doi:10.1016/0161-5890(93)90034-9

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Article

Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response.

Molecular immunology - 1 Apr 1993

Tao W, Hardardottir F, Bothwell A L

Abstract excerpt

Somatic mutations and cell lineage relationships were examined in a large panel of hybridomas derived from a single mouse 21 days after a primary immunization with NP-CGG. Among 21 lambda-bearing anti-NP hybridomas 18 distinct cell lineages were observed. Ten of the hybridomas used the V186-2 gen...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
DNA, Single-Stranded
Escherichia coli
Female
Gene Rearrangement
Genes, Immunoglobulin
Haptens
Immunoglobulin Heavy Chains
Immunoglobulin J-Chains
Immunoglobulin M
Immunoglobulin Variable Region
Immunoglobulin delta-Chains
Immunoglobulin kappa-Chains
Mice
Mice, Inbred BALB C

Source

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Identifiers

PMID: 8487778
DOI: 10.1016/0161-5890(93)90034-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8487778-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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